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Notch transcription, molecular model

Notch transcription, molecular model


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Notch transcription, molecular model

Notch transcription. Molecular model showing a strand of DNA (deoxyribonucleic acid) being acted upon by various proteins and other molecules. The main proteins are transcription factor CSL (blue) and the Notch 1 intra-cellular receptor or domain (white). Both are bound to a specific DNA sequence named HES1 promoter (Hairy and Enhancer of Split-1). The CSL-Notch interaction is stabilized by interaction with transcriptional co-activator Mastermind-like protein (MAML, orange, lower left). This transcription process is part of a wider cell signalling system called the notch signalling pathway

Science Photo Library features Science and Medical images including photos and illustrations

Media ID 9215265

© RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY

Binding Biomolecule Complex Dna Binding Proteins Domain Genetic Graphic Interacting Macromolecule Molecular Biology Neurogenic Nucleic Acid Promoter Promoter Regions Protein Structure Proteomics Receptor Sequence Signaling Signalling Tertiary Transcribing Transcription Transcription Factor Transcription Factors Biochemical Biochemistry Cutouts Deoxyribonucleic Acid Genetics Molecular Model Protein


EDITORS COMMENTS
This print showcases the intricate world of Notch transcription, a vital process in molecular biology. The image portrays a detailed molecular model where a strand of DNA is being influenced by an array of proteins and molecules. At the forefront, we see two key players: the blue-colored transcription factor CSL and the white-colored Notch 1 intra-cellular receptor or domain. Both are bound to a specific DNA sequence known as HES1 promoter. To ensure stability in this complex interaction, another protein called Mastermind-like protein (MAML) can be seen in orange on the lower left side. This co-activator enhances the CSL-Notch bond within this fascinating cell signaling system called the notch signaling pathway. The white background beautifully contrasts with the vibrant colors representing various biomolecules involved in this crucial genetic process. From binding sites to conserved sequences, homeodomain proteins to repressor proteins, every element plays its part harmoniously. With its meticulous attention to detail and scientific accuracy, this artwork provides an insightful glimpse into how genes are transcribed and regulated at a molecular level. It serves as a reminder of both the complexity and elegance that underlies life's fundamental processes. Captured by Ramón Andrade from Science Photo Library and brought to life by 3dciencia, this stunning print offers not only aesthetic appeal but also educational value for those fascinated by genetics, biochemistry, or cellular pathways.

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