Tumour suppressor protein and DNA C017 / 3645
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Tumour suppressor protein and DNA C017 / 3645
Tumour suppressor protein and DNA. Computer artwork showing a molecule of the tumour suppressor protein p53 (blue and pink) bound to a molecule of DNA (deoxyribonucleic acid, yellow and orange). p53 is crucial in multicellular organisms, where it regulates the cell cycle (the means by which cells replicate) and prevents the proliferation of cells with damaged DNA. It is produced in response to radiation and chemicals that damage the structure of DNA, when it binds to specific sequences in the DNA and halts the cell cycle. If there is only minor damage, p53 activates genes involved in DNA repair, but if the damage cannot be repaired it initiates cell death (apoptosis). p53 plays a very important role in preventing the replication of cancerous cells, so
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Media ID 9272769
© RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY
Activating Anti Cancer Binding Bound Cancer Cell Cycle Checkpoint Factor Complex Complexed Compound Compounds Dna Repair Gene Genes Genetic Genetic Material Molecules Nucleic Acid Preventative Prevention Protection Protective Proteins Proteomics Quaternary Structure Secondary Structure Strand Suppressing Tertiary Structure Transcriptional Activator Tumor Suppressor Tumour Suppressor Protein Biochemical Biochemistry Deoxyribonucleic Acid Genetics Molecular Molecular Model Protein
EDITORS COMMENTS
This print showcases the intricate relationship between a tumour suppressor protein and DNA. In this computer artwork, we witness the molecular dance of the p53 protein (depicted in shades of blue and pink) as it binds to a molecule of DNA (colored in vibrant yellows and oranges). The p53 protein is an indispensable component in multicellular organisms, playing a crucial role in regulating the cell cycle and preventing the proliferation of cells with damaged DNA. When exposed to radiation or chemicals that harm DNA's structure, p53 springs into action. It selectively attaches itself to specific sequences within the DNA strand, effectively halting the cell cycle. If only minor damage has occurred, p53 activates genes responsible for repairing DNA. However, if repairs are impossible, it initiates programmed cell death known as apoptosis. The significance of p53 cannot be overstated when it comes to thwarting cancerous growth. By preventing damaged cells from replicating uncontrollably, this remarkable protein acts as our body's guardian against malignant tumors. Ramon Andrade's stunning 3D illustration beautifully captures this complex biochemical interaction between two fundamental components: proteins and genetic material. This artwork not only highlights their structural intricacies but also underscores their vital role in safeguarding our biological integrity against potential threats like cancer.
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