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Oxalosis, light micrograph
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Oxalosis, light micrograph
Oxalosis. Light micrograph of a section through adult bone tissue affected by oxalosis (primary hyperoxaluria), showing mature bone (green), newly formed immature bone/osteoid (orange) and bone marrow. Primary hyperoxaluria results in increased excretion of calcium oxalate, with the formation of oxalate stones being common. This occurs due to the failure of the kidneys to clear calcium oxalate into urine. The calcium oxalate crystals are therefore deposited abnormally in the bone marrow forming radial, rosette-type clusters. Calcium oxalate is the main component of kidney stones. Oxalosis is a rare inborn error of metabolism and is a systemic (widespread) disease in the body. Oxalosis of bone is accompanied by calcification of joints, weakened bone
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Media ID 9247203
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Accumulated Accumulation Bone Marrow Build Up Cell Biology Cluster Clusters Cytological Cytology Deposit Deposits Excretion Histological Histology Metabolic Metabolism Osteology Stain Stained Stone Stones Tissue Abnormal Cells Condition Disorder Light Micrograph Light Microscope Section Sectioned Unhealthy
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This print from Science Photo Library showcases the intricate details of oxalosis, a rare inborn error of metabolism that affects bone tissue. The light micrograph reveals a section through adult bone tissue affected by primary hyperoxaluria, a condition characterized by increased excretion of calcium oxalate. The image highlights three distinct components: mature bone depicted in green, newly formed immature bone or osteoid in orange, and the presence of bone marrow. In individuals with primary hyperoxaluria, the failure of kidneys to clear calcium oxalate into urine leads to abnormal deposits within the bone marrow. These deposits form radial, rosette-type clusters composed mainly of calcium oxalate crystals. Oxalosis not only affects bones but also has systemic implications throughout the body. It is often accompanied by calcification of joints and weakened bones. Calcium oxalate is known as the main component of kidney stones; therefore, its accumulation within various tissues can lead to significant health complications. This visually striking micrograph provides valuable insights into the cellular and anatomical aspects underlying this disorder. By shedding light on these microscopic features, it contributes to our understanding of both normal and abnormal biological processes related to metabolism and skeletal health.
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