Sickle Cell Anaemia Collection

Haemoglobin S, molecular model F006 / 9601
Haemoglobin S. Molecular model of the mutant form of haemoglobin (haemoglobin S) that causes sickle cell anaemia. This is deoxyhaemoglobin S, the molecule in its non-oxygen bound state

Thickened skull, MRI scan
Thickened skull. Magnetic resonance imaging (MRI) scan of an axial section through the head of a 22-year-old patient, showing thickening of the trabecular (spongy) bone of the skull

Haemoglobin S, molecular model
Haemoglobin S. Molecular model of the mutant form of haemoglobin (haemoglobin S) that causes sickle cell anaemia. This is deoxyhaemoglobin S, the molecule in its non-oxygen bound state

Sickle cell anaemia, light micrograph C015 / 6395
Sickle cell anaemia. Light micrograph of a blood smear showing normally rounded red blood cells that have become curved, elongated sickle-shaped cells

Coloured LM of blood in sickle cell anaemia
Sickle cell anaemia. Coloured light micrograph of a blood smear showing distorted red blood cells in sickle cell anaemia (drepanocytosis)

Artwork of red cells in sickle cell disease
Artwork based on a scanning electron micrograph (SEM), showing deformed red blood cells in sickle cell anaemia (drepanocytosis), a hereditary blood disease that affects black people

Sickle cell anaemia, artwork
Sickle cell anaemia. Computer artwork of normal red blood cells (erythrocytes, red) and red blood cells affected by sickle cell anaemia (pink)

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"Sickle Cell Anaemia: Unveiling the Molecular Culprit and its Devastating Effects" Haemoglobin S, a genetic mutation of haemoglobin, plays a pivotal role in sickle cell anaemia. Represented by the intricate molecular model F006/9601, this abnormal haemoglobin distorts red blood cells into a sickle shape. The impact of this condition extends beyond mere visual representation. MRI scans reveal the consequences on the skeletal system, with thickened skulls becoming apparent. The repeated mention of these scans emphasizes their significance in understanding the disease's manifestations. However, it is crucial to delve deeper into the microscopic world to comprehend how sickle cell anaemia affects individuals at a cellular level. Light micrograph C015/6395 showcases distorted red blood cells characteristic of this disorder. Coloured LM images further highlight abnormalities within blood samples affected by sickle cell anaemia. Artwork depicting red cells afflicted by sickle cell disease brings forth an artistic interpretation that captures both scientific accuracy and emotional depth. These illustrations serve as poignant reminders of the challenges faced by those living with this condition daily. Sickle cell anaemia demands attention not only for its physical impacts but also for its psychological toll on patients' lives. Artistic portrayals convey emotions associated with living with this chronic illness while raising awareness about its prevalence and importance in medical research. Through molecular models like Haemoglobin S and diagnostic tools such as MRI scans, we gain insight into the complexities surrounding sickle cell anaemia's pathophysiology. Combined with light microscopy imagery and evocative artwork representing affected red blood cells, we are reminded that behind every scientific discovery lies human stories waiting to be told – stories that deserve our empathy and support in finding effective treatments for this debilitating disease.