Base Excision Repair Collection

Endonuclease IV molecule. Molecular model of the endonuclease IV restriction enzyme EcoRV (grey) bound to a cleaved section of DNA (deoxyribonucleic acid, blue, orange and pink)

DNA polymerase with DNA F006 / 9559
DNA polymerase with DNA. Molecular model of human DNA polymerase beta (beige) complexed with a molecule of DNA (deoxyribonucleic acid, red and blue)

Bacteriophage restriction enzyme F006 / 9531
Bacteriophage restriction enzyme. Molecular model of the restriction enzyme endonuclease V (yellow) from the bacteriophage T4 complexed with DNA (deoxyribonucleic acid, red and blue)

Endonuclease IV molecule F006 / 9480
Endonuclease IV molecule. Molecular model of the endonuclease IV restriction enzyme EcoRV (beige) bound to a cleaved section of DNA (deoxyribonucleic acid, blue, red and green)

Oxoguanine glycosylase complex F006 / 9318
Oxoguanine glycosylase complex. Computer model showing an 8-Oxoguanine glycosylase (OGG1) molecule (beige) bound to a section of DNA (deoxyribonucleic acid, red and blue)

Oxoguanine glycosylase complex F006 / 9307
Oxoguanine glycosylase complex. Computer model showing an 8-Oxoguanine glycosylase (OGG1) molecule (beige) bound to a section of DNA (deoxyribonucleic acid, red and blue)

Methyladenine glycosylase bound to DNA C014 / 0877
Methyladenine glycosylase bound to DNA. Computer model showing a molecule of human DNA-3-methyladenine glycosylase (purple) in complex with DNA (deoxyribonucleic acid, green and orange)

Methyladenine glycosylase bound to DNA. Computer model showing a molecule of human DNA-3-methyladenine glycosylase (purple) in complex with DNA (deoxyribonucleic acid, blue and orange)

Bacteriophage restriction enzyme C015 / 6443
Bacteriophage restriction enzyme. Molecular model of the restriction enzyme endonuclease V (brown) from the bacteriophage T4 complexed with DNA (deoxyribonucleic acid, green and pink)

Bacteriophage restriction enzyme C015 / 6442
Bacteriophage restriction enzyme. Molecular model of the restriction enzyme endonuclease V (blue) from the bacteriophage T4 complexed with DNA (deoxyribonucleic acid, yellow and pink)

Oxoguanine glycosylase complex C013 / 8886
Oxoguanine glycosylase complex. Computer model showing a molecule of human aG DNA repair glycosylase (right) bound to an DNA molecule (left)

Oxoguanine glycosylase complex C013 / 8884
Oxoguanine glycosylase complex. Computer model showing an 8-Oxoguanine glycosylase (OGG1) molecule (green) bound to a section of DNA (deoxyribonucleic acid, pink and blue)

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"Unraveling the Secrets of Base Excision Repair: A Molecular Dance" In the intricate world of DNA repair, base excision repair (BER) emerges as a crucial mechanism to maintain genomic integrity. At its core, BER involves a series of coordinated steps orchestrated by various enzymes and protein complexes. The process begins with the recognition and removal of damaged bases by specialized glycosylases such as oxoguanine glycosylase complex F006/9318 and methyladenine glycosylase bound to DNA C014/0877. These vigilant guardians identify lesions like oxidized guanine or abnormal methylated adenines, ensuring their timely elimination. Once detected, these glycosylases create an opening in the DNA helix, allowing endonucleases like Endonuclease IV molecule F006/9480 to step in. With surgical precision, they cleave the phosphodiester backbone at specific sites near the damaged base, creating a gap that needs immediate attention. Enter another key player - DNA polymerase. This versatile enzyme acts as a molecular builder by adding new nucleotides complementary to the undamaged strand. Guided by its fidelity-enhancing subunits like F006/9559 or simply working solo, it fills in the missing information with utmost accuracy. But wait. The repaired segment is not yet complete without proper sealing. Ligases join forces here; they skillfully reconnect the newly synthesized fragment with adjacent DNA strands through phosphodiester bonds. As if this intricate choreography wasn't enough for BER's success story, additional actors make their appearance on stage. Bacteriophage restriction enzyme F006/9531 ensures foreign genetic material doesn't infiltrate while maintaining genome stability. Together, these molecular ballet dancers orchestrate base excision repair – an elegant symphony safeguarding our genetic blueprint against potentially harmful mutations. Understanding this dance unlocks insights into diseases linked to faulty BER mechanisms and paves the way for innovative therapeutic interventions.